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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sajjabi, Josh | RP | Worcester Hearts | 19 | 10/24/1984 | Newcastle | RSA | Right | Right | 6' 4" | 190 lbs | - |
| Sakal, Max | SP | Baton Rouge Red Sticks | 19 | 11/05/1984 | Phoenix | USA | Left | Left | 6' 7" | 195 lbs | - |
| Sanchez, Alex | LF | Baton Rouge Red Sticks | 19 | 09/05/1984 | Santo Domingo | DOM | Left | Left | 6' 2" | 195 lbs | - |
| Sanchez, Victor | RP | Rochester Roosters | 18 | 04/28/1985 | Managua | NCA | Right | Right | 6' 6" | 190 lbs | - |
| Sato, Masahiko | CF | Worcester Hearts | 19 | 03/21/1984 | Kawasaki | JPN | Left | Left | 6' 1" | 180 lbs | - |
| Sawai, Kiyotake | RP | New Mexico Aztecs | 18 | 03/16/1985 | Tokyo | JPN | Right | Right | 6' 5" | 195 lbs | - |
| Scott, Liam | SP | New Mexico Aztecs | 18 | 10/09/1985 | Christchurch | ENG | Right | Right | 6' 2" | 185 lbs | - |
| Shelnutt, Justin | RP | Colorado Springs 14ers | 20 | 10/09/1983 | Cortlandt | USA | Right | Right | 6' 8" | 200 lbs | - |
| Shin, Gwon-beom | SP | Chicago Fire Dogs | 18 | 05/04/1985 | Seoul | KOR | Left | Right | 6' 1" | 180 lbs | - |
| Sho, Seisaku | RP | Chicago Fire Dogs | 19 | 11/23/1984 | Shimonoseki | JPN | Right | Right | 5' 11" | 175 lbs | - |
| Shumate, Tyler | SP | Lincoln Larks | 19 | 12/18/1984 | Miami | USA | Left | Left | 5' 11" | 160 lbs | - |
| Sierra, Brian | RF | Fort Worth Cowboys | 19 | 11/04/1984 | Scottsdale | USA | Right | Right | 6' 0" | 185 lbs | - |
| Sifuentes, Edwin | C | Rochester Roosters | 19 | 09/29/1984 | Arica | CHI | Right | Right | 5' 10" | 170 lbs | - |
| Silvas, Antonio | SP | Dayton Aviators | 19 | 05/16/1984 | Levittown | PUR | Right | Right | 6' 3" | 180 lbs | - |
| Silverman, Roger | 2B | Dayton Aviators | 19 | 04/06/1984 | Munich | GER | Right | Right | 6' 1" | 190 lbs | - |
| Smith, Mike | LF | Smokey Mountain 'Shiners | 18 | 02/21/1985 | Victoria | USA | Right | Right | 6' 2" | 195 lbs | - |
| Smith, Ryan | CF | Rochester Roosters | 19 | 06/05/1984 | Wichita | USA | Left | Left | 6' 0" | 175 lbs | - |
| Sorber, Pete | SP | Dayton Aviators | 19 | 09/18/1984 | Los Angeles | USA | Right | Right | 6' 1" | 175 lbs | - |
| Souders, Billy | C | Worcester Hearts | 18 | 03/29/1985 | Grantsville | USA | Switch | Right | 6' 6" | 200 lbs | - |
| Spall, Caiden | 1B | Smokey Mountain 'Shiners | 20 | 07/25/1983 | Brockton | USA | Right | Right | 5' 11" | 185 lbs | - |
| Sparks, Bobby | SP | Smokey Mountain 'Shiners | 18 | 03/18/1985 | Gallipolis | USA | Right | Right | 6' 4" | 185 lbs | - |
| Steele, Jude | RP | Baton Rouge Red Sticks | 18 | 06/14/1985 | May Pen | JAM | Right | Right | 6' 2" | 175 lbs | - |
| Stenseth, David | LF | New Mexico Aztecs | 19 | 09/29/1984 | Albany | USA | Right | Right | 6' 3" | 190 lbs | - |
| Stoner, John | C | Lincoln Larks | 19 | 08/10/1984 | Tell City | USA | Right | Right | 5' 10" | 180 lbs | - |
| Strader, Stephon | C | Huntsville Rocketeers | 18 | 07/05/1985 | St. Petersburg | USA | Right | Right | 6' 6" | 205 lbs | - |
| Streets, Neal | C | Smokey Mountain 'Shiners | 19 | 02/01/1984 | Brooklyn | USA | Left | Right | 6' 0" | 180 lbs | - |
| Stringfellow, Wayne | C | Dayton Aviators | 19 | 09/06/1984 | Coralville | USA | Switch | Right | 6' 2" | 200 lbs | - |
| Sunaga, Yuu | RP | Baton Rouge Red Sticks | 18 | 01/18/1985 | Seiro | JPN | Right | Right | 6' 1" | 170 lbs | - |
| Swinson, Nick | RP | Baton Rouge Red Sticks | 20 | 11/04/1983 | Boise | USA | Right | Right | 6' 3" | 180 lbs | - |
