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| Sunday, October 30th , 2022 |
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| Drafted RP Nick Mountain in the 2022 first-year player draft (Round 12, Pick 7, 241st overall pick). |
| Drafted SP Ryan Goins in the 2022 first-year player draft (Round 17, Pick 7, 361st overall pick). |
| Saturday, October 15th , 2022 |
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| Activated SP Gabriel Smithhart from the injured list. |
| Activated CL Mo Caples from the injured list. |
| Activated RP Preston Kaiser from the injured list. |
| Saturday, September 24th , 2022 |
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| Placed CL Mo Caples on the 10-day injured list, retroactive to 09/23/2022. |
| Friday, September 23rd , 2022 |
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| Activated SP David Davis from the injured list. |
| Placed SP Gabriel Smithhart on the 10-day injured list, retroactive to 09/22/2022. |
| Wednesday, September 21st , 2022 |
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| Placed RP Preston Kaiser on the 10-day injured list, retroactive to 09/20/2022. |
| Saturday, September 10th , 2022 |
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| Placed SP David Davis on the 10-day injured list, retroactive to 09/09/2022. |
| Wednesday, July 27th , 2022 |
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| Activated SP David Davis from the injured list. |
| Wednesday, July 20th , 2022 |
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| Activated SP Matt Poore from the injured list. |
| Saturday, July 16th , 2022 |
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| Activated SP Casey Lambert from the injured list. |
| Sunday, July 10th , 2022 |
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| Placed SP Matt Poore on the 10-day injured list, retroactive to 07/09/2022. |
| Saturday, July 2nd , 2022 |
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| Promoted CL Mo Caples to Advanced Prospect League Buffalo. |
| Thursday, June 23rd , 2022 |
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| Placed SP Casey Lambert on the 10-day injured list, retroactive to 06/22/2022. |
| Tuesday, June 21st , 2022 |
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| Activated RP Josh Arnold from the injured list. |
| Monday, June 20th , 2022 |
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| Activated LF Jose Moreno from the injured list. |
| Saturday, June 18th , 2022 |
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| Placed SP David Davis on the 10-day injured list, retroactive to 06/17/2022. |
| Saturday, May 28th , 2022 |
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| Received SP Juan Morales from Rookie College League Buffalo. |
| Released RP Edwin Pena. |
| Released RP Andy Fernandez. |
| Promoted SP Juan Morales to Advanced Prospect League Buffalo. |
| Promoted RP Leo Garcia to Advanced Prospect League Buffalo. |
| Promoted RP Bill Knight to Advanced Prospect League Buffalo. |
| Demoted CL Bryan Weiland to Rookie Complex League New York City (R). |
| Received SP David Davis from Advanced Prospect League Buffalo. |
| Received C Jeremy Humrich from Rookie College League Buffalo. |
| Received 3B Jung-hoon Kim from Rookie College League Buffalo. |
| Received C Manuel Salazar from Rookie College League Buffalo. |
| Received C Cory Evans from Rookie College League Buffalo. |
| Received CF David Romero from Rookie College League Buffalo. |
| Received 1B Valentin Lefevre from Rookie College League Buffalo. |
| Received C Juan Garlia from Rookie College League Buffalo. |
| Received C Joel Palmisano from Rookie College League Buffalo. |
| Received LF Angel Ortiz from Rookie College League Buffalo. |
| Received 1B Miguel Folque from Rookie College League Buffalo. |
| Received CF Bobby Delamacona from Rookie College League Buffalo. |
| Received CF Karl Frisch from Rookie College League Buffalo. |
| Received 1B Tyler Patterson from Rookie College League Buffalo. |
| Received RF Kenneth Pearson from Rookie College League Buffalo. |
| Received 2B Bill Warren from Rookie College League Buffalo. |
| Received 1B Dylan Nicolson from Rookie College League Buffalo. |
| Received 1B Jimmy LaBounty from Rookie College League Buffalo. |
| Promoted CF Mike Legault to Advanced Prospect League Buffalo. |
| Promoted C Cale Golebiowski to Advanced Prospect League Buffalo. |
| Promoted 1B Bobby Cervone to Advanced Prospect League Buffalo. |
| Received 2B James Williams from Advanced Prospect League Buffalo. |
| Received CF Joe Phillips from Advanced Prospect League Buffalo. |
| Released 3B Gabe Espino. |
| Released C Manuel Salazar. |
| Released C Carlos Romero. |
| Released RF Kenneth Pearson. |
| Released LF Angel Ortiz. |
| Released 1B Miguel Folque. |
| Released CF Bobby Delamacona. |
| Released SS Danny Ruiz. |
| Released RF Marcos Moreno. |
| Released RF Carlos Garcia. |
| Released CF Karl Frisch. |
| Released C Juan Garlia. |
| Released 1B Tyler Patterson. |
| Released 3B Jung-hoon Kim. |
| Released C Cory Evans. |
| Released 2B Cory Peek. |
| Friday, May 13th , 2022 |
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| Placed LF Jose Moreno on the 10-day injured list, retroactive to 05/10/2022. |
| Placed RP Josh Arnold on the 10-day injured list, retroactive to 05/10/2022. |
| Monday, May 2nd , 2022 |
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| Received CL Nelson Castro from Rookie College League Buffalo. |
| Received RP Edwin Pena from Rookie College League Buffalo. |
| Received RP Ji-hoon Kim from Rookie College League Buffalo. |
| Received SP Josh Arnold from Rookie College League Buffalo. |
| Received RP Josh Massey from Rookie College League Buffalo. |
| Received RP Gabriel Morales from Rookie College League Buffalo. |
| Promoted RP Julio Salazar to Double A Indianapolis. |
| Promoted RP Sam Lewis to Advanced Prospect League Buffalo. |
| Promoted SP Jose Morales to Advanced Prospect League Buffalo. |
| Promoted SP Mike Myrdal to Advanced Prospect League Buffalo. |
| Promoted SP David Davis to Advanced Prospect League Buffalo. |
| Promoted RP Ramon Aranda to Advanced Prospect League Buffalo. |
| Promoted RP Danny Torres to Advanced Prospect League Buffalo. |
