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| Sunday, December 4th , 2022 |
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| Signed Pitching Coach Ryan McElfish. |
| Wednesday, November 16th , 2022 |
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| Received RP Chris Lewis from Major League Houston. |
| Received LF Chad Huffman Jr. from Major League Houston. |
| Received RF Bryan Hall from Major League Houston. |
| Sunday, October 16th , 2022 |
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| Activated RP Dylan Hicks from the injured list. |
| Saturday, October 8th , 2022 |
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| Activated SP Ramon Ortiz from the injured list. |
| Activated CL Mike Brodsky from the injured list. |
| Thursday, October 6th , 2022 |
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| Placed SP Ramon Ortiz on the 10-day injured list. |
| Saturday, October 1st , 2022 |
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| Placed CL Mike Brodsky on the 10-day injured list, retroactive to 09/28/2022. |
| Monday, September 5th , 2022 |
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| Activated 2B Chris Wegge from the injured list. |
| Saturday, August 27th , 2022 |
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| Activated SP Mike Holton from the injured list. |
| Monday, August 15th , 2022 |
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| Activated RP Mike Brodsky from the injured list. |
| Sunday, August 14th , 2022 |
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| Placed SP Mike Holton on the 10-day injured list, retroactive to 08/13/2022. |
| Wednesday, August 10th , 2022 |
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| SP Mike Holton was designated for assignment. |
| Tuesday, August 9th , 2022 |
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| Placed 2B Chris Wegge on the 10-day injured list, retroactive to 08/08/2022. |
| Saturday, July 30th , 2022 |
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| Placed RP Mike Brodsky on the 10-day injured list, retroactive to 07/29/2022. |
| Monday, June 27th , 2022 |
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| Received RP Olaf Hoffman from Major League Houston. |
| Sunday, June 19th , 2022 |
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| Placed RP Dylan Hicks on the 10-day injured list, retroactive to 06/18/2022. |
| Monday, May 2nd , 2022 |
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| Promoted C Ramiro Fuentes to Major League Houston. |
| Promoted 2B Cesar Rodriguez to Major League Houston. |
| Promoted RF Brendan Zeno to Major League Houston. |
| Promoted C Carel van Eerden to Major League Houston. |
| Promoted RP Toshifumi Sato to Major League Houston. |
| Promoted SP Adel bin Mustafa to Major League Houston. |
| Promoted SP Ryan Kassan to Major League Houston. |
| Promoted SP Matt Meek to Major League Houston. |
| Promoted SP Troy Quill to Major League Houston. |
| Promoted RP Alex Coria to Major League Houston. |
| Promoted RP Joe Farrell to Major League Houston. |
| Promoted RP Dylan Hicks to Major League Houston. |
| Promoted RP Jon Lowers to Major League Houston. |
| Promoted RP Luis Minjarez to Major League Houston. |
| Promoted RP Gertjan Schouwenaar to Major League Houston. |
| Promoted RP Will Nawrocki to Major League Houston. |
| Promoted C Andrew Scharbach Johnson to Major League Houston. |
| Promoted 2B Chris Wegge to Major League Houston. |
| Promoted 3B Jason Coleman to Major League Houston. |
| Promoted 3B Jin-seok Hyeon to Major League Houston. |
| Promoted LF Brian Cecchi to Major League Houston. |
| Promoted LF John Mitchell to Major League Houston. |
| Promoted CF Yong-hun Kim to Major League Houston. |
| Promoted RF Lan-fang Ding to Major League Houston. |
| Promoted RF Gabe Hamilton to Major League Houston. |
| Promoted RF Manny Ramirez to Major League Houston. |
| Saturday, April 2nd , 2022 |
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| Activated RP Gertjan Schouwenaar from the injured list. |
