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| Tuesday, October 18th , 2022 |
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| RP Tim Williams retired from professional baseball. |
| LF Mike Perez retired from professional baseball. |
| RF Tony Pitchford retired from professional baseball. |
| CF Luis Salazar retired from professional baseball. |
| Monday, May 2nd , 2022 |
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| Promoted RF Corey Hamilton to Major League Miami. |
| Promoted 2B Bobby Velasco to Major League Miami. |
| Promoted C Matt Doyle to Major League Miami. |
| Promoted 2B Sterling Newsome to Major League Miami. |
| Promoted CF Kory Powers to Major League Miami. |
| Promoted CF Jacob Lindemuth to Major League Miami. |
| Promoted SS Nick Mills to Major League Miami. |
| Promoted 1B Randy Butler to Major League Miami. |
| Promoted 1B Jim Howse to Major League Miami. |
| Promoted 1B Jonathan Rhodes to Major League Miami. |
| Promoted 3B Joe Wheatley to Major League Miami. |
| Promoted SS Jeff Moore to Major League Miami. |
| Promoted CF Malik Sanders to Major League Miami. |
