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| Saturday, October 30th , 2021 |
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| Drafted SP Mario Llano in the 2021 first-year player draft (Round 1, Pick 6, 6th overall pick). |
| Saturday, September 4th , 2021 |
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| CL Sam Payno was designated for assignment. |
| Thursday, July 22nd , 2021 |
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| Demoted CF Ryan Edwards to Advanced Prospect League Worcester. |
| Sunday, May 2nd , 2021 |
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| Promoted SP Corey Jones to Major League Boston. |
| Promoted RP Sam Payno to Major League Boston. |
| Promoted LF Peter Dailey to Major League Boston. |
| Promoted SS Kyle Schroeder to Major League Boston. |
| Promoted RP David Guin to Major League Boston. |
| Promoted 2B Mezyan Tsalani to Major League Boston. |
| Promoted 3B Roberto Alarcon to Major League Boston. |
| Monday, February 8th , 2021 |
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| Received 1B Joe Lightfoot from Major League Boston. |
| Friday, January 8th , 2021 |
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| Received 2B Jon Coomer from Major League Boston. |
