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| Saturday, October 30th , 2021 |
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| Drafted CF Travis DeZarn in the 2021 first-year player draft (Round 2, Pick 11, 29th overall pick). |
| Drafted C Justin Bragg in the 2021 first-year player draft (Round 9, Pick 11, 155th overall pick). |
| Drafted 2B Grayson Florez in the 2021 first-year player draft (Round 11, Pick 11, 191st overall pick). |
| Tuesday, October 19th , 2021 |
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| RF Dennis Wickens retired from professional baseball. |
| RP David Lowrance retired from professional baseball. |
| Thursday, August 26th , 2021 |
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| SP Roger McCrary was designated for assignment. |
| Sunday, May 2nd , 2021 |
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| Promoted CL Chad Justice to Major League Detroit. |
| Promoted SP Mike Kendrick to Major League Detroit. |
