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| Monday, October 18th , 2021 |
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| 3B Arturo Flores retired from professional baseball. |
| RP Hector Campa retired from professional baseball. |
| Sunday, July 11th , 2021 |
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| SS Salem Adler was designated for assignment. |
| Sunday, May 2nd , 2021 |
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| Promoted 1B Ray Osolin to Major League Detroit. |
| Promoted C Gabe Espinoza to Major League Detroit. |
| Promoted LF Tyrese Stephens to Major League Detroit. |
| Promoted C Danny Coffer to Major League Detroit. |
| Promoted CF Sergio Pena to Major League Detroit. |
| Promoted SP Josh Van Leuven to Major League Detroit. |
| Promoted SP Luke Laurent to Major League Detroit. |
| Promoted SP Efrain Johnson to Major League Detroit. |
| Promoted SP Jordan Brown to Major League Detroit. |
| Promoted CF Jon Nelson to Major League Detroit. |
