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| Saturday, October 30th , 2021 |
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| Drafted SP Eric Dixon in the 2021 first-year player draft (Round 1, Pick 15, 15th overall pick). |
| Drafted CL Johnny Clark in the 2021 first-year player draft (Round 2, Pick 15, 33rd overall pick). |
| Monday, October 18th , 2021 |
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| 3B Carlos Nolasco retired from professional baseball. |
| Thursday, August 26th , 2021 |
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| Promoted RP Fred Black to Major League Las Vegas. |
| Tuesday, July 27th , 2021 |
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| Promoted RP Fred Black to Major League Las Vegas. |
| Received CL Reagan DePriest from Advanced Prospect League Boise. |
| Sunday, May 2nd , 2021 |
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| Promoted SP David Linan to Major League Las Vegas. |
| Promoted 2B Rich Perez to Major League Las Vegas. |
| Promoted RF Art Via to Major League Las Vegas. |
| Promoted 2B Andre Fowler to Major League Las Vegas. |
| Promoted RF Mario Ramirez to Major League Las Vegas. |
| Promoted RF Corey Egidio to Major League Las Vegas. |
| Promoted SS Billy Quiroga to Major League Las Vegas. |
| Promoted SP Marcos Arturo to Major League Las Vegas. |
