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| Tuesday, December 28th , 2010 |
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| Promoted LF Neal Lasher to Advanced Prospect League Birmingham. |
| Promoted SS Gian-Carlo Aquilina to Advanced Prospect League Birmingham. |
| Received RP Chris Cross from Advanced Prospect League Birmingham. |
| Received SP Clay Perillo from Advanced Prospect League Birmingham. |
| Received RP Mark Reardon from Advanced Prospect League Birmingham. |
| Received RP Brett Acquavella from Advanced Prospect League Birmingham. |
| Received RP Mike Slaughter from Advanced Prospect League Birmingham. |
| Received LF Chris Benford from Advanced Prospect League Birmingham. |
| Received RF J.J. Fisch from Rookie College League Louisiana State. |
| Received 1B Mike Wheeler from Rookie College League Louisiana State. |
| Demoted RP Brian Melton to Rookie College League Louisiana State. |
| Demoted RP Jorge Elizondo to Rookie College League Louisiana State. |
| Demoted SP Jon Sutton to Rookie College League Louisiana State. |
| Demoted RP Omar Gonzalez to Rookie College League Louisiana State. |
| Demoted RP Danny Lee to Rookie College League Louisiana State. |
| Wednesday, December 1st , 2010 |
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| Released 2B Alan Reid. |
| Saturday, November 20th , 2010 |
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| Promoted RP Mike Slaughter to Advanced Prospect League Birmingham. |
| Promoted 2B Shaw English to Advanced Prospect League Birmingham. |
| Promoted SS Jermaine Dingle to Advanced Prospect League Birmingham. |
| Promoted LF Chris Benford to Advanced Prospect League Birmingham. |
| Received RP Clay Perillo from Rookie College League Louisiana State. |
| Received C Ernesto Medina from Advanced Prospect League Birmingham. |
| Received 3B Dante Musante from Advanced Prospect League Birmingham. |
| Received LF Caleb Thibodeaux from Rookie Complex League Houston (R). |
| Received 1B Won-chul Shin from Rookie Complex League Houston (R). |
| Received 3B Jose Zaragoza from Rookie Complex League Houston (R). |
| Received LF Warren Benshoof from Rookie Complex League Houston (R). |
| Received 2B Ryan Knight from Rookie Complex League Houston (R). |
| Received 3B John Smith from Rookie Complex League Houston (R). |
| Demoted RP Atsuhiro Ito to Rookie College League Louisiana State. |
| Demoted RP Jose Loria to Rookie College League Louisiana State. |
| Demoted C Pedro Rodriguez to Rookie College League Louisiana State. |
| Demoted LF Jermija Uspensky to Rookie College League Louisiana State. |
| Promoted SP Clay Perillo to Advanced Prospect League Birmingham. |
| Received SP Jon Sutton from Rookie College League Louisiana State. |
| Received C Jorge Gonzalez from Advanced Prospect League Birmingham. |
| Received 2B Alan Reid from Advanced Prospect League Birmingham. |
| Received SS Gian-Carlo Aquilina from Advanced Prospect League Birmingham. |
| Received CF Kanenori Amano from Advanced Prospect League Birmingham. |
| Received 1B James Bailey from Advanced Prospect League Birmingham. |
| Received LF Chris Edwards from Rookie College League Louisiana State. |
| Demoted C Alpha Vason to Rookie College League Louisiana State. |
| Demoted 1B Mike Wheeler to Rookie College League Louisiana State. |
| Demoted SS Aarnoud Ruiter to Rookie College League Louisiana State. |
| Demoted RF Luis Carrillo to Rookie College League Louisiana State. |
| Demoted CF Charlie Till to Rookie College League Louisiana State. |
| Demoted 1B Jose Solano to Rookie College League Louisiana State. |
| Received CL David Wagner from Advanced Prospect League Birmingham. |
| Received SP Jeff Wise from Rookie Complex League Houston (R). |
| Received LF Neal Lasher from Rookie Complex League Houston (R). |
| Received RF Eric Ege from Advanced Prospect League Birmingham. |
| Received 3B Sean Blount from Rookie Complex League Houston (R). |
| Demoted RP Juan Villegas to Rookie College League Louisiana State. |
| Demoted 2B Ryan Knight to Rookie College League Louisiana State. |
| Demoted 3B John Smith to Rookie College League Louisiana State. |
| Demoted LF Warren Benshoof to Rookie Complex League Houston (R). |
| Demoted CF Chris Edwards to Rookie Complex League Houston (R). |
| Monday, November 15th , 2010 |
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| Released RF Jonathan Plair. |
| Monday, November 1st , 2010 |
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| Released 2B Rafael Rodriguez. |
| Friday, October 29th , 2010 |
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| Signed Pitching Coach Noe Lazu to a 2-year contract extension. |
| Monday, October 18th , 2010 |
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| Activated RP Atsuhiro Ito from the injured list. |
| Activated CL Brian Melton from the injured list. |
| Friday, October 1st , 2010 |
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| Activated SS Aarnoud Ruiter from the injured list. |
| Wednesday, September 29th , 2010 |
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| Placed CL Brian Melton on the 10-day injured list, retroactive to 09/28/2010. |
| Saturday, September 25th , 2010 |
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| Placed SS Aarnoud Ruiter on the 10-day injured list, retroactive to 09/24/2010. |
| Tuesday, September 7th , 2010 |
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| Activated SS Rafael Rodriguez from the injured list. |
| Saturday, August 14th , 2010 |
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| Placed SS Rafael Rodriguez on the 10-day injured list, retroactive to 08/13/2010. |
| Tuesday, July 27th , 2010 |
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| Activated RP Mike de Alba from the injured list. |
| Saturday, July 24th , 2010 |
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| Placed RP Atsuhiro Ito on the 10-day injured list, retroactive to 07/23/2010. |
| Wednesday, July 14th , 2010 |
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| Placed RP Mike de Alba on the 10-day injured list, retroactive to 07/13/2010. |
| Saturday, July 10th , 2010 |
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| Activated C Pedro Rodriguez from the injured list. |
| Sunday, June 20th , 2010 |
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| Placed C Pedro Rodriguez on the 10-day injured list, retroactive to 06/19/2010. |
| Saturday, June 12th , 2010 |
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| Received RP Danny Ramirez from Rookie College League Louisiana State. |
| Received RP Danny Ramirez from Rookie College League Louisiana State. |
| Wednesday, May 26th , 2010 |
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| Activated RP Jesus Rodriguez from the injured list. |
| Tuesday, April 13th , 2010 |
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| Placed RP Jesus Rodriguez on the 10-day injured list, retroactive to 04/10/2010. |
