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| Saturday, October 14th , 2000 |
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| RP Juan Roa retired from professional baseball. |
| 1B Mike Brantley retired from professional baseball. |
| 2B Jose Lopez retired from professional baseball. |
| RF Carlos Vargas retired from professional baseball. |
| Saturday, October 7th , 2000 |
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| Activated RP Rafael Serna from the injured list. |
| Activated CF Jason Robinson from the injured list. |
| Activated RP Mickey Williams from the injured list. |
| Sunday, September 10th , 2000 |
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| Activated RP Victor Rolon from the injured list. |
| Friday, September 8th , 2000 |
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| Placed RP Mickey Williams on the 10-day injured list, retroactive to 09/07/2000. |
| Friday, August 25th , 2000 |
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| Placed CF Jason Robinson on the 10-day injured list, retroactive to 08/24/2000. |
| Saturday, August 19th , 2000 |
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| Placed RP Victor Rolon on the 10-day injured list, retroactive to 08/18/2000. |
| Monday, July 17th , 2000 |
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| Activated SP Larry Topp from the injured list. |
| Friday, June 23rd , 2000 |
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| Placed RP Rafael Serna on the 10-day injured list, retroactive to 06/22/2000. |
| Tuesday, June 13th , 2000 |
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| Placed SP Larry Topp on the 10-day injured list, retroactive to 06/12/2000. |
| Wednesday, May 3rd , 2000 |
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| Received C Joe Amero from Under 24 Providence. |
| Demoted C Wayne Kelly to Under 20 Worcester. |
| Promoted RF Chad Uecker to Triple A Montreal. |
| Promoted LF Adam Collingwood to Triple A Montreal. |
| Promoted 1B Justin Lawrence to Double A Miami. |
| Promoted RF Chris Kerns to Double A Miami. |
| Promoted C Juan Trevino to Under 24 Providence. |
| Promoted 2B Fernando Baker to Under 24 Providence. |
| Promoted LF Monte Murillo to Under 24 Providence. |
| Promoted CF Jason Robinson to Under 24 Providence. |
| Received C Wayne Kelly from Under 20 Worcester. |
| Signed Manager Marshall Neal. |
| Signed Pitching Coach Ashton Seitz. |
| Signed Hitting Coach Eric Heuer. |
| Monday, April 3rd , 2000 |
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| Promoted SP Ronnie Jacobs to Major League Boston. |
| Promoted SP Mobumasu Tsuji to Major League Boston. |
| Promoted RP Andy Quinones to Major League Boston. |
| Promoted RF Harrison Powell to Major League Boston. |
| Promoted 1B Chris Tarter to Major League Boston. |
| Promoted SP Willie Cantu to Under 24 Providence. |
| Promoted C Eric Larremore to Under 24 Providence. |
| Promoted 3B Ryan Ream to Under 24 Providence. |
| Promoted SS Robby Verret to Under 24 Providence. |
| Promoted 3B Jose Sanchez to Under 24 Providence. |
| Promoted 1B Stanford Parent to Under 24 Providence. |
| Received SP William Fruits from Under 20 Worcester. |
| Received SP Octavio Anaya from Under 20 Worcester. |
| Received RP Rafael Serna from Under 20 Worcester. |
| Received RP Sergio Nucci from Under 20 Worcester. |
| Received RP Victor Rolon from Under 20 Worcester. |
| Received RP Juan Roa from Under 20 Worcester. |
| Received RP Tim Burger from Under 20 Worcester. |
| Received C Wayne Kelly from Under 20 Worcester. |
| Received SS Danny Ybarra from Under 20 Worcester. |
| Received CF Alejandro Ramirez from Under 20 Worcester. |
| Received 2B Jose Lopez from Under 20 Worcester. |
| Promoted RP Roberto Medina to Under 24 Providence. |
| Promoted RP Luis Gutierrez to Under 24 Providence. |
| Promoted 2B Victor Jara to Under 24 Providence. |
| Promoted RP Josh Hulett to Under 24 Providence. |
| Promoted RP Ryan Martindale to Under 24 Providence. |
